Waitrose commercial director Mark Williamson, is to retire at the end of January 2017, while Rupert Thomas, currently marketing director, will move into the commercial director role.
Rupert's replacement will be announced at a later date.
Mark joined Waitrose in 2004 and has been on its management board for 10 years. He will continue as Chairman of the Leckford Estate - the Waitrose Farm - a role he took up earlier this year.
Managing director Rob Collins said: "Mark has done a fantastic job and achieved great things on the commercial front; he's been a valued board colleague, bringing wisdom and experience to our work. I'm delighted that he continues as Chairman of Leckford so that we will still benefit from his contribution to our business.
"Rupert, our very successful marketing director, also has strong commercial experience. He joined Waitrose in 2003 having spent over 10 years in various commercial and marketing roles; his first job with us was heading our grocery and fruit buying teams. He is the ideal candidate to pick up the baton from Mark and I wish them both well for the future."