Masked men robbed Focus DIY store in Newport, taking a "significant amount" of cash.
Police are investigating the incident, which occurred at the Audley Avenue store sometime between 10.55pm and 11.30pm on Monday night.
A statement from West Mercia police confirmed that two key holders for the business had made their way to the store at around 11pm after being notified by their security company that the store alarm had been activated.
They carried out checks and reset the alarm, but noticed that one of the sensors was still activated. Suddenly, two unknown men wearing balaclavas and dressed in black burst in through the door behind them, demanding that they open the safe and hand over the money from inside.
One of the men, who is described as around 6ft tall with a big build, is said to have shouted "Take me to the money".
A spokesperson for Focus said that an investigation was being handled by West Mercia police and the company had no further information.
Acting detective inspector Billy Scott at Telford CID said: "Feeling threatened by the men, the two women understandably co-operated with the offenders and took them to the safe. One of the women opened it up and then both women were pushed to the floor.
"The two men quickly emptied the safe and then made off back through the door they had originally entered the premises through. At this stage it is not clear exactly how much money was stolen as a result of this robbery but it is thought to be a significant amount of cash."
Police are keen to hear from anyone who may have seen a silver hatchback car, possibly a VW Golf, being driven suspiciously close to the premises on Monday night. Anyone with information about the robbery should call Telford police on 0300 333 3000.